Patch-clamp studies of slow potential-sensitive potassium channels in longitudinal smooth muscle cells of rabbit jejunum
نویسندگان
چکیده
منابع مشابه
effects of mitochondrial atp-sensitive potassium channels on the proliferation and secretion of human airway smooth muscle cells.
bronchial asthma is the common chronic inflammatory disease and is characterized by chronic airway inflammation, airway remodeling, and airway hyperreactivity (ahr). aim of this study was to investigate the effects of mitochondrial atp-sensitive potassium channels (mitokatp) on the proliferation and secretion of human airway smooth muscle cells (hasmcs). hasmcs were treated with the serum from ...
متن کاملCharacterization of the ATP-sensitive potassium channels (KATP) expressed in guinea pig bladder smooth muscle cells.
ATP-sensitive K+ (KATP) channels play an important role in the regulation of smooth muscle membrane potential. To investigate the properties of KATP channels in guinea pig urinary bladder smooth muscle cells, fluorescence-based assays were carried out with the membrane potential-sensitive probe bis-(1,3-dibutylbarbituric acid)trimethine oxonol [DiBAC4(3)]. The prototypical channel openers, incl...
متن کاملPotassium channels and proliferation of vascular smooth muscle cells.
Potassium channels play a major role in the immediate and long term regulation of vascular smooth muscle function.1 The activity of these ion channels determines and regulates cell membrane potential, which, in turn, regulates the open state probability of voltage-gated Ca channels, Ca influx, and intracellular Ca . The concentration of intracellular Ca not only regulates the immediate contract...
متن کاملSingle nisoldipine-sensitive calcium channels in smooth muscle cells isolated from rabbit mesenteric artery.
Single smooth muscle cells were enzymatically isolated from the rabbit mesenteric artery. At physiological levels of external Ca, these cells were relaxed and contracted on exposure to norepinephrine, caffeine, or high levels of potassium. The patch-clamp technique was used to measure unitary currents through single channels in the isolated cells. Single channels were selective for divalent cat...
متن کاملVoltage-Clamp Studies on Uterine Smooth Muscle
These studies have developed and tested an experimental approach to the study of membrane ionic conductance mechanisms in strips of uterine smooth muscle. The experimental and theoretical basis for applying the double sucrose-gap technique is described along with the limitations of this system. Nonpropagating membrane action potentials were produced in response to depolarizing current pulses un...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1983
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1983.sp014774